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KMID : 0603820090150040327
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Journal of Experimental & Biomedical Science
2009 Volume.15 No. 4 p.327 ~ p.333
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Modulation of Rit Activation by the Alpha Subunit of Go
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Yang Chul-Min
Ghil Sung-Ho
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Abstract
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Heterotrimeric GTP binding proteins, G-proteins, mediate signal transduction generated by neurotransmitters and hormones. Among G-proteins, Go proteins are the most abundant in brain and classified as a member of Gi family. Ras-like protein in all tissues (Rit), one of the small GTPases, is a member of a Ras superfamily and identified as an important regulator of neuronal differentiation and cell transformation. Recently, we have reported that Rit functioned as a candidate downstream effector for alpha subunit of Go proteins (Goα) and regulated neurite outgrowth triggered by Goα activation. In this study, we showed that the GTPase domain of Goα contributed to the direct interaction with Rit. We also demonstrated that Goα could lead to an increase of Rit activity suggesting that Rit play a role as a downstream effector of Goα.
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KEYWORD
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Domain, G-protein, G-protein coupled receptor, GTPase, Rit, Ral
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